Àireamh Cas Florfenicol: 73231-34-2 Foirmle Molecular: C12H14Cl2FNO4S
2,2-dichloro-n-[(1r,2s)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
AQUAFEN FLORFENICOL NUFLOR
[r-(r*, r*)]-n-[1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide
[R-(R*,S*)]-2,2-DICHLORO-N-[1-(FLUOROMETHYL)-2-HYDROXY-2-[4-(METHYLSULFONYL)PHENYL]ETHYL]ACETAMIDE
SCH-25298
(r-(r*,s*))-methyleste
2,2-dichloro-n-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl
4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl)-benzenesulfonicaci
Florfeniol
FLUPROFEN
Fluorothiamphenicol
Sch-25298, Aquafen
Acetamide, 2,2-dichloro-N-(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-4-(methylsulfonyl)phenylethyl-
2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide
Aquaflor
Aquafen, Nuflor, SCH-25298, [R-(R*,S*)]-2,2-Dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl ]acetamide
2,2-Dichloro-N-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)acetamide
2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamid
| Rubha leaghaidh | 153° |
| Dùmhlachd | 1.451 ± 0.06 g / cm3 (ro-innse) 1.1782 (tuairmse garbh) |
| teòthachd stòraidh | 2-8 ° C |
| so-thuigsinn | Soluble ann an ethanol gu 25mM agus ann an DMSO gu 100mM |
| gnìomhachd optigeach | Chan eil |
| Coltas | Geal gu Off-White |
| Purity | ≥98% |
Tha Florfenicol na antibiotic fluorinated le speactram farsaing agus mar thoradh air thiamphenicol (Nì Àireamh 21357).Tha e gnìomhach an aghaidh aonaranachd clionaigeach daonna de bacteria enteric, a’ gabhail a-steach E. coli, Klebsiella, Enterobacter, Citrobacter, P. mirabilis, agus Salmonella (MIC).50s = 6.3-12.5 μg/ml).Tha Florfenicol cuideachd gnìomhach an aghaidh aonaranachd clionaigeach de dhiofar pathogens slighe analach crodh agus muc-mhara, a’ toirt a-steach P. multocida, A. pleuropneumoniae, agus B. bronchiseptica (MIC).50s = 0.25-4 μg/ml).Tha e a’ cur bacadh air gnìomhachd peptidyl transferase ann an ribosomes 70S a tha dealaichte bho E. coli nuair a thèid a chleachdadh aig dùmhlachd de 1 mM.Chaidh foirmlean anns a bheil florfenicol a chleachdadh ann an làimhseachadh galairean analach gabhaltach ann an crodh.
Is e seòrsa de dhroga antibacterial a th’ ann.Tha e air a chleachdadh mar dhrogaichean antimicrobial lighiche-sprèidh airson a bhith a’ làimhseachadh ghalaran bactaraidh mucan, cearcan is iasg.Tha èifeachdas math aige ann a bhith a’ làimhseachadh galair gabhaltach mucan, cearcan agus iasg air adhbhrachadh le bacteria mothachail, gu sònraichte airson a bhith a’ làimhseachadh ghalaran analach agus galairean caolan.
